Crassocephalum crepidioides, also called ebolo, thickhead, redflower ragleaf, or fireweed, is an erect annual slightly succulent herb growing up to 180cm tall. Its use is widespread in many tropical and subtropical regions, but is especially prominent in tropical Africa. Its fleshy, mucilaginous leaves and stems are eaten as a vegetable, and many parts of the plant have medical uses. However, the safety of internal use needs further research due to the presence of plant toxins.[2]
Crassocephalum crepidioides contains the hepatotoxic and tumorigenic pyrrolizidine alkaloid, jacobine.[4][2] However, in another study, it is shown that the antitumor activity and macrophage nitric oxide produce action. [5]
Fu, P.P., Yang, Y.C., Xia, Q., Chou, M.C., Cui, Y.Y., Lin G., "Pyrrolizidine alkaloids-tumorigenic components in Chinese herbal medicines and dietary supplements", Journal of Food and Drug Analysis, Vol. 10, No. 4, 2002, pp. 198-211 [permanent dead link]
Tomimori, Koh, et al. "Antitumor activity and macrophage nitric oxide producing action of medicinal herb, Crassocephalum crepidioides." BMC complementary and alternative medicine 12.1 (2012): 78.
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